WebStructural and biochemical characterization of the WT CYP105AS1 reveals that this CYP is an efficient compactin hydroxylase, but that predominant compactin binding modes lead mainly to the ineffective epimer 6-epi-pravastatin. To avoid costly fractionation of the epimer, the enzyme was evolved to invert stereoselectivity, producing the ... Web4OQS: Crystal structure of CYP105AS1. You are using a web browser that we do not support. Our website will not work properly.
Structure-Based Engineering of CYP105AS1 for the Production …
WebCYP105AS1Protoporphyrin Ix Containing Fe NCBI National Center forBiotechnology Information Search 4OQS: Crystal Structure Of Cyp105as1 Biological Unit for 4OQS: monomeric; determined by author and by software (PISA) Molecular Components in 4OQS * Click molecule labels to explore molecular sequence information. Citing MMDB WebStructure-Based Engineering of CYP105AS1 for the Production of High-Value Molecules A thesis submitted to the University of Manchester for the degree of Doctor of Philosophy … fnaf pregnant fanfiction
Current state and future perspectives of cytochrome P450 …
WebDec 13, 2016 · The authors used P. chrysogenum to express the original compactin gene cluster from P. citrinum, along with the gene CYP105AS1 —encoding a cytochrome P450—from Amycolatopsis orientalis (also known as Streptomyces orientalis ), converting the compactin to pravastatin. WebStructure of a CYP105AS1 mutant in complex with compactin Coordinates PDB Format Method Oligo State monomer Ligands 1 x HEM: PROTOPORPHYRIN IX CONTAINING FE (Non-covalent) , , ... WebJul 11, 2008 · Purity: > 98%. C 20 H 28 O 3 = 316.4. Physical Description: Powder COA MSDS SDF [ Source ] The branch of Platycladus orientalis [ Biological Activity or Inhibitors ] 1. 15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities. fnaf powerpoint