WebApr 12, 2024 · We compared the effector functions and cytotoxicity of these CAR-T cell variants against a group of tumor cell lines with a wide range of EpCAM expression as … The exact function of EpCAM is currently being elucidated, but EpCAM appears to play many different roles. EpCAM was first found to play a role in homotypic cell adhesion. This means that EpCAM on the surface of one cell binds to the EpCAM on a neighboring cell thereby holding the cells together. The adhesions mediated by EpCAM are relatively weak, as compared to some other adhesion …

EpCAM: Structure and function in health and disease

WebFeb 19, 2024 · The epithelial cell adhesion molecule (EpCAM) is one of the most frequently and intensely expressed of tumor-associated antigens, but the role that EpCAM plays in the proliferation, adhesion and migration properties of cancer cells remains unclear. In the present study, we screened several tumor cell lines and found that colorectal … WebMay 31, 2024 · EpCAM, a carcinoma cell-surface marker protein and a therapeutic target, has been primarily addressed as a cell adhesion molecule. With regard to recent discoveries of its role in signaling with implications in cell proliferation and differentiation, and findings contradicting a direct role in mediating adhesion contacts, we provide a comprehensive … princess house party catalog

The Emerging Role of EpCAM in Cancer and Stem Cell Signaling

WebThe EPCAM gene provides instructions for making a protein known as epithelial cellular adhesion molecule (EpCAM). This protein is found in epithelial cells, which are … WebJul 11, 2024 · EpCAM is a cell adhesion molecule that plays important roles in the formation and functions of adhesive structures and polarity. However, EpCAM is highly expressed … WebApr 22, 2013 · Injection of tumor cells in mice more than 30 years ago resulted in the discovery of an epithelial antigen, later defined as a cell adhesion molecule (EpCAM). Although EpCAM has since evoked... princess house party builders 2022