WebNov 5, 2024 · Thymoglobulin® and Grafalon® are 2 polyclonal rabbit anti-thymocyte globulin (ATG) used in allogeneic hematopoietic stem cell transplantation (allo-HSCT) to prevent graft rejection and graft-versus-host disease (GvHD). Differences in manufacturing lead to different types and concentrations of antibodies in each product. WebANTI-THYMOCYTE GLOBULIN (RABBIT) - INJECTION (AN-ti THIGH-mow-site GLOB-ue-lin) COMMON BRAND NAME(S): Thymoglobulin. USES: This medication is used to prevent …
Combining post-transplant cyclophosphamide with antithymocyte globulin …
WebAbstract. The pharmacokinetics of the distribution and elimination of polyclonal rabbit antithymocyte globulin (ATG) following intravenous infusion was studied in patients who had received renal allografts. ATG concentration was measured using a new enzyme-linked immunoabsorbent assay (ELISA) for the Fc portion of rabbit IgG. WebApr 15, 2024 · Objective In Japan, immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG), and cyclosporine A (CsA) is the standard of care in patients with aplastic anemia (AA) who are not indicated for stem-cell transplantation, although some patients may experience relapse. This study assessed the e … phh home loans clearwater florida
Antithymocyte immunoglobulin (rabbit) Drugs BNF NICE
WebThymoglobuline (anti-thymocyte globulin [rabbit], rATG) is a purified, pasteurised, immunoglobulin G, obtained by immunisation of rabbits with human thymocytes. This immunosuppressive product contains cytotoxic antibodies directed against antigens expressed on human T-lymphocytes. The mechanism of action for how it suppresses the … WebStorage & Handling. Thymoglobulin® is supplied for injection as a single-dose 10-mL vial containing 25 mg of rabbit anti-thymocyte globulin (ATG) sterile lyophilized powder intended for reconstitution prior to intravenous administration. 1. Store in refrigerator at 2°C to 8°C (36°F to 46°F) 1. Protect from light 1. WebJan 22, 2024 · The increase from 2.5 to 5 mg/kg of rabbit anti-thymocyte globulin dose in reduced intensity conditioning reduces acute and chronic GVHD for patients with myeloid malignancies undergoing allo-SCT ... phh hospital