Webb1 maj 2024 · Sin1-mediated cell proliferation and invasion of PCa cells occurs by regulating mTORC2-AKT signaling, epithelial-mesenchymal transition and matrix … Webb28 maj 2012 · See all SIN1 primary antibodies Description Rabbit polyclonal to SIN1 Host species Rabbit Tested applications Suitable for: WB, IP, IHC-P more details Species reactivity Reacts with: Human …
SIN-1 cytotoxicity to PC12 cells is mediated by thiol ... - PubMed
Webb27 okt. 2013 · Sin1 phosphorylation suppresses mTORC2 kinase activity towards phosphorylating Akt in vitro. (a,b) HEK293T cells were transfected with the indicated Flag-tagged Sin1 constructs. At 36 h... Webb11 aug. 2015 · SIN1 phosphorylation mediates a positive feedback loop between Akt and mTORC2 Summary The mechanistic target of rapamycin complex 2 (mTORC2) regulates cell survival and cytoskeletal organization by phosphorylating its AGC kinase substrates; however, little is known about the regulation of mTORC2 itself. fitech mpg improvement
Sin1 promotes proliferation and invasion of prostate
Webb19 nov. 2024 · S ty1/Spc1- in teracting protein 1 (Sin1), also known as mitogen-activated protein kinase ( MAPK) a ssociated p rotein (MAPKAP)1, was first identified in 1999 in fission yeast Schizosaccharomyces pombe as an adaptor protein interacting with Sty1 (also known as Spc1), a member of the eukaryotic stress-activated protein kinase … Webb17 okt. 2016 · Thus, localization at the plasma membrane is a key aspect of mTORC2 regulation. 9 An oncogenic mutation in the PH domain of mSin1 that blocks mSin1-mediated mTOR inhibition leading to... Webb14 nov. 2024 · Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2 November 2024 Journal of Molecular Cell Biology 11 (2) DOI: 10.1093/jmcb/mjy065 License CC BY 4.0... can having gas make your lower back hurt