Thiotepa route
WebThe radiomimetic action of thiotepa is believed to occur through the release of ethylenimine radicals which, like irradiation, disrupt the bonds of DNA. One of the principal bond disruptions is initiated by alkylation of guanine at the N-7 position, which severs the linkage between the purine base and the sugar and liberates alkylated guanines. WebThis will help prevent kidney problems and keep your kidneys working well. Thiotepa sometimes causes nausea, vomiting, and loss of appetite. However, it is very important …
Thiotepa route
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WebDec 5, 2024 · Thiotepa given by the IP route was teratogenic in rats at doses ≥ 3 mg/kg (21 mg/m 2), approximately equal to the maximum recommended human therapeutic dose, based on body-surface area. Thiotepa was lethal to rabbit fetuses at a dose of 3 mg/kg (41 mg/m 2 ), approximately two times the maximum recommended human therapeutic dose … WebFind information on Thiotepa (Tepadina) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
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WebApr 1, 2024 · Thiotepa belongs to the group of medicines called alkylating agents. It interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by thiotepa, other effects will also occur. Some of these may be serious and must be reported to your doctor. WebThiotepa is approved to treat: Bladder cancer. Breast cancer. Malignant pleural effusion, malignant pericardial effusion, and malignant peritoneal effusion. Ovarian cancer. …
WebThiotepa may be given rapidly intrave- nously in doses of 0.3–0.4 mg/kg at intervals of 1–4 weeks. The drug has also been given intra- venously in doses of 0.2 mg/kg or 6 mg/m2daily for 4 or 5 days at intervals of 2–4 weeks. Thiotepa has also been given intramuscularly in doses of 15–30 mg in various schedules.
WebThiotepa for injection is an alkylating drug indicated for treatment of adenocarcinoma of the breast or ovary, for controlling ... Ingestion: This material is fatal through the oral route in small amounts. This material can cause serious health effects and death. May cause damage to organs. Chronic Symptoms: Causes damage to organs ... st winnings primary schoolWebFeb 16, 2024 · Thiotepa Riemser is indicated, in combination with other chemotherapy medicinal products: with or without total body irradiation (TBI), as conditioning treatment prior to allogeneic or autologous haematopoietic progenitor cell transplantation (HPCT) in haematological diseases in adult and paediatric patients; st winnings rc church kilwinningWebRoute & Dosage Malignant Lymphomas Adult: IV 0.3–0.4 mg/kg q1–4wk Intratumor 0.6–0.8 mg/kg directly into tumor q1–4wk Intracavitary 0.6–0.8 mg/kg instilled through same tubing used for paracentesis at intervals of at least 1 wk Intravesicular 60 mg in 30–60 mL of distilled water instilled into bladder to be retained for 2 h once/wk ... st winnolls